B. Frank Gupton, Ph.D.
Research Professor and Interim Chair, Department of Chemical and Life Science Engineering
Phone: (804) 828-4799
Virginia Commonwealth University
School of Engineering
Department of Chemical and Life Science Engineering
West Hall, Room 438
601 West Main Street
P.O. Box 843028
Richmond, Virginia 23284-3028
- B.S., chemistry, University of Richmond
- M.S., biochemistry, Georgia Institute of Technology
- Ph.D., chemistry, Virginia Commonwealth University
- 1976-86: Celanese Corp. – senior project leader, research and development
- 1987-93: Hoechst-Celanese Corp. – project manager, commercial development
1994-2007: Boehringer Ingelheim Chemicals, Inc. – executive director, process development
The Gupton research group is focused on the development and application of new technologies that will streamline organic synthesis through process intensification. The goal of process intensification is to increase the overall efficiency and selectivity of chemical reactions by using novel chemistry and/ or running reactions under more extreme process conditions (temperature and pressure). We are interested in applying these principals towards the development of new catalyst systems that can be used in concert with continuous chemical processing (flow reactor technology) to streamline the synthesis of pharmaceutical active ingredients (API’s).
We have developed a series of palladium catalyst systems that can be used in cross-coupling reactions for batch and continuous operations and we are currently using these catalysts in the preparation of several API target molecules. These catalysts are composed of metal nanoparticles supported on novel carbon-based platforms such as graphene or carbon nanotubes. Our group has direct access to a wide variety of surface characterization methodologies to characterize these materials which have provided fundamental insights into their unusual catalytic activity.
We are also actively involved in the evaluation and integration of continuous analytical methodologies with continuous chemical processing in order to provide real time feedback and optimization of our processes.
1 . Moussa, S.; Siamaki, A; Gupton, F.; and El-Shall, M., ACS Catal. 2012, 2 145-154.
2. Siamaki, A.; Khder, V.; Abdelsayed; El-Shall, M.; and Gupton , F., J. Catalysis, 279 (2011) 1-11